Healing flow

In an aneurysm, the recirculating blood flow, driven by the change in shape of the artery itself, becomes pathophysiological. The consequent weakening and enlargement and further change in shape of the wall can lead to rupture.

The MFM is constructed of three-dimensional braided wire mesh which aims at transforming the blood flow into a laminar flow as blood passes through the porous layers of the MFM.

The MFM aims at promoting a physiological remodeling of the flow inside the aneurysm while maintaining branch patency.

Pathophysiological blood flow before MFM implantation Blood flow after MFM implantation

Peak wall shear stress prior to MFM implantation  Peak wall shear stress after MFM implantation 

The lamination of blood flow aims at reducing the shear stress along the artery wall, to prevent further weakening of the artery wall and reduce the risk of rupture. 

The laminar flow aims at the formation of an organized thrombus while the formation of endothelial tissue on the MFM is observed. 

The MFM design aims at enhancing the perfusion of organs, 
to avoid serious ischemic complications and improve quality of life. 

Computational fluid dynamics modeling of blood flow inside the aneurysm before MFM implantation (left) and after MFM implantation (right). 

Intended use 

The Aortic MFM®  currently bears CE-mark approval for the endovascular treatment of patients with aortic aneurysms involving at least one branch, high surgical risks, and a morphology suitable for endovascular repair. 

Features 

• Maintaining branch vessel patency and improving perfusion 
• Endothelialization and integration, as the uncovered device allows endothelial tissue to be generated on the braided structure 
• The flared ends of the Aortic MFM® aim at ensuring device compliance with the aortic wall and optimal sealing at both proximal and distal landing zones to avoid the risk of type I and III endoleaks 
• Durability based on the the multilayer braided design of the cobalt alloy wires 
• Low Profile, push-pull delivery system 

Intended use 

The Peripheral MFM® is no longer on the market due to changes in medical device regulation in Europe. The device was previously CE-marked  for endovascular treatment of patients with unruptured peripheral artery aneurysms (iliac, visceral, popliteal and subclavian arteries), with morphology suitable for endovascular repair.  

Features 

• Maintaining branch vessel patency 
• Endothelialization and integration, as the uncovered device allows endothelial tissue to be generated on the braided structure 
• Durability based on the multilayer braided design of the cobalt alloy wires 

An aneurysm is a weak spot in a blood vessel that bulges out like a balloon. This happens when the vessel wall becomes fragile, causing blood to flow in a way that puts extra pressure on the weak area. 

If left untreated, this constant pressure—pushing against the vessel with every heartbeat—can cause the aneurysm to burst, leading to severe internal bleeding, which can be life-threatening. 

Aneurysms can develop in various parts of the body, including the brain, abdomen, and legs. While they affect people differently, they are a serious health issue that impacts many lives each year. 

Since the 1990s, doctors have increasingly used a less invasive procedure called endovascular procedure to treat aneurysms. This approach involves guiding a tiny medical device through a thin tube (catheter) inside the blood vessel to reinforce the weakened area of the vessel.  

Compared to traditional open surgery, endovascular therapy requires only small incisions, which means patients recover faster and spend less time in the hospital. 

Since their introduction, endovascular procedures have grown to represent today most of the aneurysm interventions in Europe and the USA.

MFM® devices are designed with a special three-dimensional braided mesh that aims to control blood flow inside an aneurysm. The concept relies on the fact that instead of allowing blood to swirl turbulently, these devices aim to smooth out the flow, making it more gentle and controlled. 

By reducing the pressure and stress on the weakened artery wall—two major factors that can cause an aneurysm to burst—MFM® devices aim at lowering the risk of dangerous bleeding 

Because the MFM® devices are not covered, they allow to keep flow to the branch arteries, which in turn should reduce the risk of paraplegia and other issues caused by restricted blood flow.. 
Through smoothening of the flow, the MFM® aims at creating an organized thrombus in the aneurysm.